This smoothie recipe may be changed in several delicious ways depending on your preference when it comes to a margarita. Using frozen papaya allows you to have the nutritional benefits of the fruit while providing ice at the same time. You can also try fresh papaya and add ice cubes to get to the consistency that you desire. Also, try agave nectar in place of the simple syrup for a taste combination to die for. This way you will be gaining the health benefits of agave and experiencing the magic of fermented agave (aka tequila) at the same time!